Prescribed to treat type 2 diabetes, the AstaZeneca/Bristol-Meyers Squibb drug Onglyza mimics hormones to trigger insulin release. The FDA has required label warnings about an increased risk for acute pancreatitis. In 2013, the Journal of the American Medical Association reported a substantially increased risk for pancreatic cancer with the drug. The FDA has also required a warning label about increased risk for heart failure.

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