Proton pump inhibitors (PPIs), which include prescription and over-the counter medications such as omeprazole, Nexium, Prilosec, and Prevacid, are used to reduce stomach acid production and to treat heartburn, indigestion, gastritis, and GERD/acid reflux. PPIs are associated with a 33% relative risk increase for chronic kidney disease, as well as increased risk for gastric cancer with long-term use following H. pylori eradication therapy.