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Elmiron (pentosan polysulfate sodium), manufactured by Janssen Pharmaceuticals, is the only FDA-approved drug to treat interstitial cystitis, which causes chronic pain in the bladder and pelvis area. In 2019, a physician at Emory Eye Center in Atlanta, GA reported patients who had been taking the medication for 15 years had developed unusual changes in their macula, the central part of the retina. A patient review at Kaiser Permanente in Northern California confirmed that patients who had significant exposure to Elmiron showed definite signs of eye damage, including retinal maculopathy, which may result in vision loss.

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