Invokana
The FDA has required Invokana, an SGLT2 drug used in type 2 diabetes, as well as off-label in those with type 2 diabetes, to carry a black box warning for higher risk for leg and foot amputations. In addition, the FDA has mandated a label change with warnings that the drug can cause a serious and potentially life-threatening infection known as Fournier’s Gangrene.
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